European Stars And Stripes (Newspaper) - July 21, 1987, Darmstadt, Hesse                                Dont undertook meat including poultry dont under reheat already cooked foods Luri Iionia from Wood Hunt one step closer to a malaria vaccine Byjah Ziegler United press internationale Ven before the cause of malaria was discovered a Century ago people were looking for ways 1o prevent the disease that claims at least 1 million lives annually. Now scientists have come a step closer to creating a vaccine that will Stop the malaria parasite fans milled by the bite of the female Anopheles Mosquito a team fed by researchers at los Waller Reed army medical Center succeeded in producing immunity using a vaccine made Tram a protein mimicking that Lound on the surface of one stage of the parasite that causes the disease they tested the vaccine on themselves and then to see if it worked exposed themselves to malaria in a recent study. It s one of the great traditions of Medicine said or. W. Ripley Baotou Lead author of the study referring to self experimentation. But Ballou an infectious disease officer at Walter Reed conceded his family thought a were  the catch was that immunity occurred in Only one Volunteer of the eight who participated the others developed malaria but were quickly cured. The team does nol know How Long the immunity will last nor Are the researchers certain Yel How to make a vaccine that will work in More people. Malaria transmitted by the bile of an infected Mosquito exists in Central America South America Africa the Indian subcontinent. Southeast Asia Korea and Indonesia. There Are Lour species of the parasite that cause the disease in humans. The current research is based on the kind plasmodium Lac Parum that causes most malaria fatalities estimated to exceed t million a year. A vaccine is particularly important because there has been a worldwide resurgence of the disease caused by increasing numbers of drug resistant parasites and insecticide resistant mosquitoes. Travellers used to protect themselves with Mosquito netting now they can Lake drugs the most Well known of which is chlo Roque before during and after a visit loan area where malaria is endemic but resulting resistance is Only temporary. The new vaccine induces the body to attack the first stage of malaria infection known As the Sporozoite stage. Sporozoites Are injected by infected mosquitoes and within a few hours Migrate to the liver where they Are transformed into merozoites. These later break out and Lodge inside red blood cells. The vaccine Gilsett is made by inserting a piece of Sporozoite genetic material into bacteria. The bit of genes induces the bacteria to produce protein that trigger a Host s immune system to launch an attack on the sporozoites and neutralize them ii is important to neutralize All the so Rozaitis because even one can cause disease. Malaria life Cycle 2 in tie Mosquito s gut gamete yes reproduce creating zygotes which form cysts on the insect s stomach h. Ujj within the cysts spore zones infectious Carrier organisms mature unit the cysts rupture. Some escaping so Noiles reach the Mosquito s salivary glands. Fertilized game oocyte zygote ruptured cyst Mosquito extracts blood con Taining malaria Gamet Cylas Parent cells of malaria parasites from an infected human. Dont allow contamination from raw to cooked foods i sporozoites in the Mosquito s Saiva enter a new human a ctn a the insect extracts mood in red blood cells merozoites reproduce and mature into either  which invade other red blood cells or male or female gamete yes which transmit malaria to new victims via mosquitoes. Sporozoites Migrate to the human Host s liver where they mature into merozoites their next stage in development sources National Institute of allergy end infectious diseases. National geographic. Dpi graphic a. Jaegerman tuesday july 21, 1987 the stars and stripes Page 17