European Stars And Stripes (Newspaper) - January 16, 1988, Darmstadt, Hesse Single Gene May determine sex a biological switch"1 for turning other genes on or off by Harold m. Schmeck or. New York times n International Loam of scientists has discovered what appears to be a Gene Hinl Dot gimmes whether a human embryo will grow into a Mulc or a Lemang. Whenever that Gene is present in the chromosomes of Iha it Tiszl egg. The scientists believe the let us will develop Cultis and grow to be a male. When re is absent the fetus will develop ova pics and become a newly discovered Gene re believed to act As a biological up which. Luming other genes on or Oil scion lists described the discovery As a major Slop in understanding the process in which a single fertilized egg develops into a human being. The mechanism by which Trie so elem individual in determined has been a subject of scientific speculation since the Lime of Aristotle said the report published in the journal cell As an individual develop a Complex series d hormonal and other influences occur leading to the production of All the so Ual characteristics. Mate or female. But inc trigger Lorall the changes that Lake place m the male appears to be the action of a single gone located on the y chromosome Vichich is found normally in male Ceils. Tho noddy identified Gene is named Adf Lor Lestes determining Factor. What we Havo found is a major step toward understanding the age old question of sex said or David c. Page. The principal author of the report. He is a research Mccow at the Whitchead Insl Lule id Bior Nedical research of the Massachusetts instituted technology in Cambridge. His colleagues in the research Aie Al Iha University of British Columbia and the University of Helsinki. We suspect Hinl what we have discovered is the sex determining Gene no Only in humans bul in All other mammals As Well said or Page Shamain Impact Over inc next Low years will to in opening Upa whole new area lot Basic or University an expert on sexual . Said the study appeared to be very comprehensive and was of fundamental the discovery Ollie Gene might among of her things Lead to of other genes that Are Lumen on and off by this Mailer switch thus increasing knowledge of he process of sexual Cweren ligation. The research Laam found essentially Inq Erma Bombeck same Gene in other mammalian species including apes monkeys dogs cattle rabbis and goats and something closely similar in mice. The deciding dilute Fence in genetic endowment Between male and female has Long been known to be on the y chromosome the male sex chromosome. The Normal genl a complement for the mate is 12 pairs of non sex chromosomes and a 23nd pair thai consists of me x and one y. For Lama Las the 23rd pair consists of iwo x chromosomes. For Many years in was unclear whether the Kay sax determinant was a single Gene of several genes situated Al various scattered Point son Tho y chromosome. The now studies indicate that the Lesley determining Factor is situated on Ana Small specific part of the y chromosome and that it is very probably just one Gene. A Large portion of the Gene has been cloned or isolated and grown to the Laboratory enabling detailed studies of is properties. The Gene is Iha blueprint Lor making a particular protein. White this Gene product has not yet been completely identified enough of us Climi Stryhas been revealed to indicate thai in is one of a class of proteins that bind o one or the other of the main chemicals of heredity dam doxy Ribyn Udvic acid or rna . This evidence suggests strongly that the testes determining Gene is important in deciding when and whether or not. Other genes related to sexual development Are switched on. Dam is the Active substance of the genes. Several kinds of rna translate the genetic instructions of Iha Gene into the process of manufacturing products by the living cell. A the Plarl a human embryo has ail the other genetic instructions it needs to become a male or a inmate but it becomes a male Only it the testes determining actor starts the process of development along the mate pathway. Normally o mate Wal develop when the embryo has received an x chromosome Isom its Mother and a y chromosome from the lather. But the research that led to the now report demonstrated hat maleness can be conferred by a minute piece of the y chromosome even when that piece is inherited Wilh iwo Complete x chromosomes. These mates Are sterile but otherwise usually physically Normal. Conversely to individual who inherits an x and a � sometimes develops As a female when a crucial part of Tho v chromosome in missing. Such females often do not mature sex any. Study of such cases helped the scientists discover the Gene for the Lestes determining actor. Geneticists Reler to people whose sex was determined by such unusual combinations As sex reversed the scientists reporting in cell said Thoy had discovered one person who had two xxx chromosomes but was male because he also had one Haff of 1 percent of the y chromosome. They have also studied a person who is female in Spile of having 99,8 percent of the y chromosome. Cases such As these were useful by narrowing the location of the tests determining Gene. Page said All the mates Hie Arou phad examined had the minute portion of the y chromosome believed to contain Tho Gene has about 140,000 base parrs. The Dan subunits. The y Chown octto has an estimated 70million such us buns. Elites aside the discovery could my be used to alter the sex o a Lelus because transplanting the Gane would lace enormous technical difficulties and the outcome would be highly Uncertain. A Normal embryo gets an x chromosome from the Mother x or a v chromosome from the father determining its my. have found what appears to be a single Gene on the y chromosome called the tastes determining Factor or Adf they believe it Start male sexual development. Adf Normal male Normal a Mew discovery of Adf was aided by study of rare eases in which people s sex chromosomes did not match their sex. These people had inherited abnormal chromosomes from their fathers whose top had migrated from the y chromosome to the x chromosome some offspring had two x chromosomes one of them carrying top they developed As mates. Others with an x chromosome end a y chromosome lacking to developed As female. Adf migrates paternal cell one of the hardest things in the world to explain is the Dit Terence Between being married and living with someone. As an advocate of Orange blossoms and Long mortgages i usually end up throwing around a couple of High class words like commit Lenl and responsibility to and then when my opponent losses Back phrases Ikic. Love does t need a piece of paper or look Tiow Many people gel stuck in unhappy relationships t crumble. I Don t have a Good answer Lor it. Somehow 1 can t seem to put my Ling i on that elusive bit of intimacy that makes marriage in bom relationships one shares the same bathroom feeds Iho collective dog. Eals together shops together sleeps Side by Side and yet. Recently on a to show called a year in the Lite Inq widowed lather no longer wanted to continue his relationship to a contemporary without marriage. She could t understand ii. They were doing just line the Page 16 the stars and stripes Way Lay were going to dinner sleeping together and still hanging on to their own Independence end careers. He looked at her and said sadly but we Don t worry about things you Havo lobe married to understand that line. Anyone can play House but a couple struggling to pay for one is something else. A philosopher once said marriage is our Las our Best Chance to grow he could be right. Everything up until the time you walk Down the aisle has been polite guarded and a Lille superficial. Returning irom the altar is a different feeling altogether. You have not contracted for a temporary position. This is a permanent career. You have just bet All your chips on the biggest Crapshoot of your Lile. But there is something else. You have agreed to Legal rights to share equally in belongings debts closets Lide Lily and children there Ere defined duties. Duties to respect one another Tell the truth listen take care of one another and be sensitive la your individual needs. Duties to preserve one another s saturday january 16,1968 Independence. This in t dating anymore whare you Compromise on whether or not to get anchovies on the Puza this is the major league of Elalio ships where there Are surprises around every Comer. We be gone through Uve Ewars. Two miscarriages five houses three children 17 cars. 23 Uncial seven camping trips 12 jobs i9banks and three credit unions. I slopped doors afler30q9. What Dol have to show Tor ii a reeling of Pride and Contentment Lor having done something that in l easy. A realization that there is someone outside of Myverl without whom i do not col whole. Maybe Iho Ditl Tonee Between living together and being married is the former is a Spectator spoil and the latter is playing i to game by Al the rules. Marriage has no guarantees. If that s what you re looking for go live Wilh a car Battery. As Lor fear Al making a mistake another philosopher said ii All. God help the Man who won marry until he Finda a perfect woman and god help him still More in he Linds ice 111, in menu to bin flu
