European Stars and Stripes (Newspaper) - November 13, 1990, Darmstadt, Hesse Harnessing genes possible cancer cure by John Barbour associated press a in september a child began to receive cells Reader list a in body and 9eneticaly altered to cure a disease that would otherwise have left her at the mercy of sow hat w0uld on Ydea it Normal people a glancing a so far 10 Melanoma victims each of whom had barely three months to live have been Given altered cells hat proved for the first time that foreign genes could of Hin Innucci int humans safely and could remain biologically Active in the human body. Coincidentally three of the first five showed dramatic shrinking of their tutors and one had Complete remission. A and the same scientists who conducted these Testa Are ready to introduce altered genes into humane to Finuf rce ? pm Plency 01 Kller cells 10 tutors to help them a s a it that Wou do Lher Wise a a a a two different therapies Are coming together a a ,pin9 the immune system to fight established cancers and Gene Transfer in which a de Isone s by insert nil a Heahy a Quot a a Boer a to hold Back the breathtaking possibilities. Ass my a a the f a ral los Quot utes a heal a in nil ii a that Means hat one of six americans died in world tha Quot radiation and chemotherapy ass Sisr me rejection of the cancer. That s the Avenue Weare and there is a sense of urgency. Or. W. French Anderson a Gene therapy researcher at a he Trade Floral cancer treatments Are surgery to remove tutors radiation to shrink or kill localized cancers and chemotherapy. The new approaches shown Here attempt to enhance the cancer fighting Power of the body a own a immune system. ,. A i 9 tumor id in Ohk ller Kells coded ,0 make More h ipe heart of cancers and make them Hafsa Vestues 3 a Mic,0sc0pic Dum Dum a also think about cells equipped with Missina Aenes that Atento acted into humans to Thwan those detect dec nature that leave numberless humans to suffer shortened lives then consider tumor cells Are removed from patient lymphocytes Are returned the strengthened lymphocytes infused along with More interleukin attack the Gnor cells. Immunotherapy tumor infiltrating lymphocytes tils Are incubated with interleukin-2, a molecule secreted by White blood cells that can have effects on other cells in the immune system. Gene Transfer lymphocytes Are White blood cells that Are a key part of the body a immune system. Cells from the patients tumor Are removed and treated using one of the methods at right. Lymphocytes can be genetically altered to better fight tumor cells. This technique involves the use of a virus which can install the new genetic information in the lymphocytes. A Karl i Nih and editor of the new journal of human Gene therapy wrote recently that he remembered Quot the fhloonf16 Hwy urdu at 3 pubic forum of one 0la Huntley sto�ra0�?zsee4h Den hav9 he inherited disease cd ind Rinak to resent the fact that a few we a meaning Frt the a presented ar9uments Strong enough to hop n the Scienta la technology which promises to give Hope to those suffering from a genetic disease a that was in 1983. A in an editorial this summer Anderson asked rhetorically what a the Rush Quot thllh/6 Ruf Nis the daily necessity to help sick people mme we Neel he a we no ,0 3 m0re ume. We need help when we Are sick. So ask tha a??lwh0 has a Quot by a mor the to live ask me if shrivelin9 ask a a Huntley i i b run arises from our human compassion for a it Russ patients will be sooner Thuro ba9un. And in coming years it could explode across in United Sta institutions a is ssh ass Ssiss. To demonstrate the safety of inserting foreign Gene human cells the byproduct was lives saved. Pieces of tutors were excised from the five and and grown outside the body with interleukin-2 a substance that encourages Lymphocyte growth in Para 1ft Winein Experiment Page 16 the stars and stripper t a tuesday november 13,1990phsssshk a7onsrem in a half a dozen other sex ments planed. Occasionally something is Aoi Nfn no in our body and immune systems Rechani that 9�wron9 but our when a group of a less diking out of control0., by years is to help the immune Skol Grok Quot �?T5 the scientists readily arts Fath ? weapon of Choice. To Lineha i a. 1___ _. A a Tiv Ces mass produced doubling an redoubling m Days. The idiosyncrasy of these cell they Home in on tutors from which they were Der cells were then re injected into the patients. Nntphn0a? 0f he Nile patients showed anti tumor eff Ien Hatiej a 27-year-old Mother had Over 30 m tutors in her lung skin and Mouth a particularly \ cancer untreatable in advanced stages. They Havi disappeared and she is Back at work. St0annph�indfpf it s Tumo was completely arrest Danho a is is Back at work teaching da�?.9 a to blvd patient had 95 percent to 98 Percy reduction m his tutors but it failed to hold for 30 d after a App h the s time the tumor was arrested after a year he slipped Back again and died last be on a 4 up Tihay the Nih team used a different Tec Sevort Nyrl h 9j wh0 was sufferin9 from a rare d its a re immunodeficiency scid which to senseless against infection and Canceri after Ftp of who used to be called Quot Bubble b disease rant Lola ton required to protect them ,raiioh9, by 9,vin9 them a Missir on hat Thyrl Deam Inase. And in fact b Transfer Thorpy la requirement for the current gent the world v 9 Are fewer than 20 cd Patk jlty9ar-� d s bl00d was taken and the to to twerp nlw9re 9,Ven for the missing Enz it billion of the n m pro fusion outside the body and 1 billion of them were infused into the child. Be Ore inn61�?T11 continue but it May a months Cauthen Remc a sults Ean be spen. One reason human non?6 Pope Are still worried about tinkering run rampant soa.hp9rhaps cr�atin9 diseases that cd done Halo k prep cols under which this world one have been carefully designed. Father of a in hse scenario a muses Anderson the three App cd Tarpy who with other scientists has s of the worst that pan happen. Quot i c of a Meton 9 that Cou a happen could sure free us. Sor a meteor coming through the
