European Stars and Stripes (Newspaper) - April 1, 2007, Darmstadt, Hesse Page 20 stars and stripes sunday april 1 2007 mouse House mimics humanity by Duncan Mansfield the associated press Oak Ridge term in one Corner of the vast Oak Ridge National Laboratory they Arent interested so much in building a bet Ter Mousetrap but in creating a vast Colony of closely crossbred mice at the Russell Laboratory for comparative and functional genomics commonly known As the mouse researchers Are building a mouse collection that resembles the human population in its diversity group Leader elis a Chesler says this firstos Itkind International project could become a plat form for a new Way of looking at human biology using the mouse As a said geneticist David Threadgill at the University of North Carolina at Chapel Hill mice have Long been used As Laboratory substitutes for humans they reproduce quickly Are easily mutated and on a genetic level Are about 85 percent identical to people but researchers say the approach used in those studies at Oak Ridge and elsewhere sex photos by Curtis Boles Oak Ridge National four of the eight different Breeds of lab mice that Are being crossbred into a new population of mice intended to mimic the genetic diversity of humans for advanced studies at Oak Ridge National Laboratory mining one Gene at a time fails to address the genetic and environmental complexity of human diseases and conditions such As obesity diabetes alcohol ism and aging it is like saying do you want a Blurry picture of Saturn or do you want to see the space be tween the rings Chesler said with the so called collaborative Cross mouse project we can get Down to that level of de the project is the result of a collaboration among some 300 geneticists from around the world their plan is to create Dis Tinct lines of mice from eight Origi Nal Breeds it will require More than 20 generations of carefully plotted though randomly selected crossbreeding and inbreeding but the result will be like taking representatives of each racial group from each geographical re Gion and putting them together and then being Able to reproduce those same individuals Over and Threadgill said the potential breakthrough is to be Able to study multiple genetic factors simultaneously aided in part by the Oak Ridge National Laboratory supercomputers it also could be the basis for de Cades of accumulated research by scientists from around the Globe on the same mouse Pool this is a very exciting said Marvin Stodolsky of the department of Energy of fice of biological and Environ mental research it will reflect the sort of diver sity have in the human population which for some technical reasons and largely political reasons Stem cells we cannot yet Harvest and he said Well the mice Are not in a Posi Tion to the million Russell lab which opened in 2004 was selected As the main site for this work Oracle ceo Lawrence j Elli sons medical foundation which has a particular interest in agree lated diseases is providing fund ing support companion projects Are under Way in Israel and Australia funded by the wellcome Trust in Jerusalem and the University of Western Australia in Perth the Russell lab offers cushy accommodations for up to res ident rodents filtered air filtered water climate controlled cages in rooms virtually sealed off from the outside world and equip ment for cryogenically freezing their embryonic offspring since the collaborative Cross work began in 2005 a Little Over 400 mouse strains have been Cre ated in Oak Ridge scientists be Lieve they will need about crossbred lines to yield via ble ones geneticist Elissa Chesler exam Ines a mouse the reproduction work could take three to five More years to Complete though researchers could begin using the mouse Pool in As Little As 18 months geneticist Rob Williams at the University of Tennessee health sciences Center in Memphis a founding member of the collaboration views Complex mouse work As the Only Way to achieve 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