European Stars and Stripes (Newspaper) - February 19, 1993, Darmstadt, Hesse                                Friday february 19, 1993 . The stars and stripes Page 5 3 drugs together May whip aids virus from wire reports Boston a promising three drug treatment seems to Block the aids virus ability to cause disease scientists said wednesday. The potential treatment which combines the Drugatz with two other drugs has been tested Only in cells growing in culture dishes. But it seems so promising that clinical trials in advanced aids patients will begins Early As Spring or. Martin Hirsch said at Massachusetts general Hospital this is an exciting new Avenue of investigation Hirsch said. But he warned that until we have Evi Dence of effectiveness in infected people it s just an other Laboratory  it is also not known whether the three drug Combina Tion is toxic to patients. There is always the potential for these drugs to interact in unfavourable ways Hirsch said. The results were reported in this week s Issue of the journal nature. Or. Dan Hoth director of the aids program at the National Institute of allergy and infectious diseases in Bethesda md., said the discovery suggests the possibility of a very exciting combination therapy approach i think that even if it does t work As an aids therapy Hoth said it suggests a whole realm of re search in which we can study the effect of drugs in the Laboratory and try to apply them in the  Hirsch said trials on 200 patients will begin at 10 can cer centers.-. The potential treatment uses two drugs already approved for aids patients at and Del plus an other Nev rapine or a pyridine on not yet approved for wide use. The idea came from a Harvard school of Medicine graduate student Yung Kang Chow in Hirschy Laboratory. Chow reasoned that aiming three drugs simultaneously at a vulnerable target might damage the virus so severely that it cannot mutate enough to repair it self. All three drugs attack a single enzyme called  which the virus needs to reproduce. In one Experiment scientists infected blood cell with the aids virus called his then waited a week until his reproduction was at its. Peak. They the added the three drug combination. Thirty five Days later the infection was no longer detectable. After 49 Days of treatment the drugs were re moved and no his reproduction was detected for the next 45 Days the balance of the Experiment. Or. Douglas Richman at the University of California san Diego said Chow s idea resembles a chess game in which several it reverse transcript task inhibitors Are positioned to Force it to make a fatal combination of  but Richman writing in nature noted that the virus is a highly mutable and wily opponent. And whether it can avoid checkmate with a Large array of alternative moves mutations is a real  in the stars and stripes 10 years ago feb. 19 1983 a russian believed to be the chief of the Kab was arrested when he walked into a trap set by the West German Federal criminal office officials said. 20 years ago feb. 19,1973 former . Service members some of them Vietnam veterans Are training the illegal Irish Republican army in guerrilla tactics British intelligence offi cers said in Belfast Northern Ireland. 30 years ago feb. 19,1963-the soviet Union informed the United states that it plans to pull several thousand troops from Cuba by March 15, diplomatic sources said. 40 years ago feb. 19,1953 an Indianapolis judge ruled that the korean conflict is not a War meaning that beneficiaries of soldiers killed there Are entitled to double indemnity settlements. 50 years ago feb. 19,1943 a continuous flow of Talent from . Radio stage and screen will soon begin travelling to every Camp and installation in the. European theater of operations officials said. World War ii 50 years ago today feb. 19 1943 the germans and italians shift the thrust of their offensive in Western Tunisia toward be Kef instead of Rebessa As German Field marshal Erwin Rommel wants Allied resistance stiffens As German tanks push through Mountain passes toward Thala and Biba. On the Southern soviet front the red army clears the germans from the Road and rail network linking Kharkov and kursk. Source 2194 Days of War w h. Smith publishers inc world almanac Book of world Zurll. Bison books corp 1981 a a the White House said $30 billion is too much to spend on a space station. But a spokeswoman said the station As depleted in drawing was not being cancelled. White House seeks to save Money on a space station from wire reports Washington president Clin ton wants Nasa to once again Rede sign the space station the White House said wednesday. Clinton officials told congressional staffers that the administration wants to abandon the current design that Calls for a $30 billion station. But Maria Romash spokeswoman for vice president Al Gore said the station was not being cancelled. Clin ton will ask Congress to spend $2.3 billion on the station in fiscal 1994, which begins oct. 1. Romash said said Nasa adminis Trator Daniel s. Goldin has been Given a mandate to Stop the Cost Over runs and manage the program More  the station s Mission is to provide an orbiting platform for the study of Long term human exposure to space and the behaviour of Industrial Materi als in weightlessness. The current design planned for four astronaut occupancy by 2000, was expected to Cost Between $30 billion and $40 billion. Groups test abortion Pill in . Labs by the new York times abortion rights groups said wednes Day that they Hud brought in the chinese version of the abortion Pill ru486 to America for testing. The push is designed to encourage the French maker of the drug to sell its own Pill in the United states or let someone else do so. Led by abortion rights mobilization a group based in new York several Abor Tion and women s rights groups said the had a spun testing the chinese version s safety on animals at undisclosed laboratories in the United states. The groups plan to seek approval soon from the food and drug administration for tests on humans. The groups said that although the French company Roussel Claf and its Par Crit i Loach St a of Germany own the european patents on the abortion Pill the Law allows anyone to test a drug or a similar compound. It is Only when an unauthorized maker tries to sell the drug that Patent infringement occurs. China however is not a party to International Patent conventions and a copy of the abortion Pill is widely used there. Toussel officials could not be reached for comment. For several years the company has re fused to apply for permission to sell ru486 in the United states because of what company officials have called the hostile climate toward abortion in Ameri Ca now however president Clinton and Fra officials have said they would Wel come an application. Fra officials said that if the request by the abortion rights groups for experiments with the drug was in Good order it would probably be approved quickly. Ru486 blocks the action of progesterone a hormone that prepares the uterus for pregnancy and prevents it from expel Ling the newly fertilized egg. Ru486 cuts off the blood to the embryo and induces bleeding and contractions that flush it out. 7 children left alone at Home die in Detroit fire Detroit a a fire killed seven children Ages 9 and under who were left Home alone and were trapped by bars on the windows of their two Story wooden House wednesday officials said. The victims were found in one room and apparently had pushed a Dresser to a window in an attempt to escape but the windows had padlocked burglar bars on them battalion chief Harold Watkins said. The House was on the City s near East Side in a neighbourhood of rundown one family Homes. The children were asphyxiated by smoke fire marshal Richard Milliner said. The fire started in the Kitchen said City arson investigator capt. William Peck. The cause was t immediately known. It was believed that All or must of the victims were children of a Man and woman who lived at the House. A Homi cide investigator at the scene speaking on condition of anonymity identified the couple As she acc Williams 34, and Leroy Lyons in his mid-30. The couple had left the children alone and arrived at the House about 20 min utes after the mid afternoon fire was re ported the homicide investigator said. After going to a Hospital the Mother was taken to police Headquarters for questioning. The father s whereabouts was t known six hours after the fire