European Stars and Stripes (Newspaper) - February 19, 1993, Darmstadt, Hesse                                Friday february f0, 1993 i . The stars and 8 ttwcs1 it tits 3 drugs together May whip aids virus from Wirt reports Boston a promising three drug treatment seems to Block the aids virus ability to cause disease scientists said wednesday. The potential treatment which combines the drug at with two other drugs has been tested Only in cells growing in culture dishes out it seems so promising that clinical trials in advanced aids patients will begin As Early As Spring or. Martin Hirsch said at Massachusetts general Hospital this is an exciting new Avenue of investigation Hirsch said. But he warned that until we have Evi Dence of effectiveness in infected people it s just an other Laboratory curiosity it is also not known whether the three drug Combina Tion is toxic to patients. There is always the potential for these drugs to interact in unfavourable ways Hirsch said. The results were reported in this week s Issue of the journal nature or. Dan Moth director of the aids program at the National Institute of allergy and infectious diseases in Bethesda my said the discovery suggests the possibility of a very exciting combination therapy  i think that even if it does t work As an aids therapy Hoth said it suggests a whole realm of re search in which we can study the effect of drugs in the Laboratory and try to apply them in the  Hirsch said trials on 200 patients will begin at 10 can cer centers. The potential treatment uses two drugs already approved for aids patients at and a i plus an other Nevi raping or a pyridine on not yet approved for wide use. \. " the idea came from a Harvard school of Medicine graduate student Yung Kang Chow in Hirsch s Laboratory. Chow reasoned that aiming three drugs simultaneously at a vulnerable target might damage the virus so severely that it cannot mutate enough to repair it self. All three drugs attack single enzyme called  which the virus needs to reproduce in one Experiment scientists infected blood cell with the aids virus called his then waited a week until his reproduction was at its Peak they the added the three drug combination. Thirty five Days later the infection was no longer detectable. After 49 Days of treatment the drugs were re moved and no his reproduction was detected  45 Days the balance of the Experiment or. Douglas Richman at the University of California san Diego said Chow s idea resembles a chess game in which several it reverse transcript task inhibitors arc  Force it to make a fatal combination of  but Richman writing in nature noted that the virus is a highly mutable and wily opponent. And whether it can avoid checkmate with a Large array of alternative moves mutations is a real  in the stars and stripes 10 years ago feb. 19,1983 a russian believed to be the chief of the Kab was arrested when he walked into a trap set by the West German Federal criminal office officials said. 20 years ago feb. 19,1973 former . Service members some of them Vietnam veterans Are training the illegal Irish Republican army in guerrilla tactics British intelligence offi cers said in Belfast Northern Ireland. 30 years ago feb. 19,1963 the soviet Union informed the United states that it plans to pull several thousand troops from Cuba by March 15, diplomatic sources said. 40 years ago feb. 19,1953 an Indianapolis judge ruled that the korean conflict is not a War meaning that beneficiaries of soldiers killed there Are entitled to double indemnity settlements. 50 years ago feb. 19,1943 a continuous flow of Talent from . Radio stage and screen will soon begin travelling to every Camp and installation in the european theater of operations officials said. World War ii 50 years ago today feb. 19 1�943 the germans and italians shift the thrust of their offensive in Western Tunisia toward be Kef instead of Rebessa As German Field marshal Erwin Rommel wants Allied resistance stiffens As German tanks push through Mountain passes toward Thala and Biba. On the Southern soviet front the red army clears the germans from  Road and rain network linking Kharkov and kursk. Source 2 9-1 0a s of War. W h Smitti pubic hets me. World Al Runac Book of world we h.  books clip1981 a the White House said $30 billion is too much to spend on space station. But spokeswoman said the station As depicted in a drawing was not being cancelled. White House seeks to save Money on a space station from wire reports Washington president Clin ton wants Nasa to once again Rede sign the space station the White House said wednesday. Clinton officials told congressional staffers that the administration wants to abandon the current design that Calls for a $30 billion station. But Maria Romash spokeswoman for vice president Al Gore said the station was not being cancelled. Clin ton will ask Congress to spend $2.3 billion on the station in fiscal 1994, which begins oct. 1. Romash said said Nasa adminis Trator Daniel s. Goldin has been Given a mandate to Stop the Cost Over runs and manage the program More  the station s Mission is to provide an orbiting platform for the study of Long term human exposure to space and the behaviour of Industrial Materi als in weightlessness. The current design planned for four astronaut occupancy of 2000, was expected to Cost Between $30 billion and $40 billion. Senate votes to Kee 9 out his infected Washington a the Senate voted thursday to prevent people infected with the aids virus from Immi grating to the United states. The 76-23 vote was a defeat for president Clinton. The ban on admitting foreigners wit the human immunodeficiency virus had been a matter of government policy that could be changed by Clinton. But thurs Day s vote would turn that policy into Alaw and any change would require an act of Congress. In approving an amendment sponsored by sen. Don Nickles r-okla., the Senate said people with the his virus could come to the country to attend conferences go on vacation or get medical treatment. But they could i stay Here permanently. Clinton Hud said during the Campaign that he intended to change the old policy to allow his positive people to visit an immigrate and aides have said he continued to support that position after he took office. But Nickles and an overwhelming number of senators disagreed with allow ing the immigration. I m afraid that this change in policy Isa very serious mistake a serious mis take that will Cost lives Nickles said of Linton s intent. It will also Cost dollars. It will Cost big  the Senate earlier thursday Defeated above by sen. Tel Ward Kennedy d-mass., that would have nullified what Nickles amendment did. Kennedy s proposal would have kept current Federal policy in place for90 Days but it would have left Clinton free to change it after that. Kennedy s measure lost on a 56-42 Vole. Nickles amendment is attached to u Bill that authorizes the government to spend Money on the National institutes of health. Compassion begins at Home said sen. Phil Gramm a Texas one of those backing the move to Lake the decision out of Clinton s hands. Kevorkian assists in 2 More suicides Watt i Ord Mich. Apr. Jack Kevorkian thursday helped two More peo ple commit suicide his lawyer s office said. The deaths bring to 15 the number of peo ple he has helped die since 1990. The actions come weeks before a new state Law makes assisting suicide a felony. The office of Kevorkian s lawyer Geof Frey i Leger and Waterford township police both confirmed the two deaths. "1 can say that there Are two victims and i have officers at the scene who Are trying to straighten it out police u. Paul Vallad said. The latest deaths were Kevorkian s fifth and sixth assisted suicides this month. The most recent prior death was monday when a 70-year-old former Security guard Hugh Gale killed himself in his Home in Rose Ville. Kevorkian a retired pathologist is an outspoken advocate of medically assisted suicides for the severely ill. Lie was charged with murder in the first three deaths but u judge dismissed the charges because Michi Gan had no Law Banning Assi u d suicide no charges have been filed in the suicides since then. He has said he will defy a new state Law due to take effect March 30, Banning assisted suicides. The Law passed in response to Kevorkian s activities. Ill be in effect for 15 months. During that time it Calls for a legislative review of the Issue