European Stars and Stripes (Newspaper) - November 18, 1990, Darmstadt, Hesse                                Page 18science amp the world lab mice with human organs join aids War Sandra Blakeslee new Yort times in a series of bold experiments Scie tial have created Laboratory mice with tiny human Organ structures a hmm intestines pan creases Lymph nodes thy muses own and in mme syst eng. The pump use g to study the viruses of Banian disease m firing human misanes. The animals whose Organ tissue Are derived from those of human fetuses provide a singular Opportunity to gauge the effectiveness of various antiviral drugs. The mice have been successfully infected with the aids virus and with two cancer viruses foal cause leukaemia. Researcher plan next to infect the with  which can damage the brains of unborn children. After that win come infections with the viruses of influenza chronic infant diarrhoea genital warts and hepatitis. Because these viruses attack Only humans h has been impossible hitherto to study them in animals. The Organ structures Are not miniature Carbon copies of duh organs but contain Complete structural subunits of each Organ and carry cad the Organ s Normal Fanti oct in duplicate with the mouse s own. The novel mice were developed by or. J. Michael Mccune an immunologist who treats aids patients at san Francisco general Hospital. A second kind of mouse carrying adult Bannan Wood cells has been developed Fay or. Donald e. Mosier an immunologist from the medical research Institute a private research Laboratory in la Jolla Calif. Both scientists announced their inventions two years ago and have made strides since then in developing the mouse human hybrids. Many of those experiments Are being done by companies recently formed by Mosker and Mccane. Researchers at Duke University Stanford University and the University of California at los Angeles have also replicated the work. Because human feta tissues Are being implanted into animate and not humans Mccune and his colleagues Are not subject to the Federal ban on the use of such tissues in medical research. The ban imposed two years ago by the department of health and human services was intended to prevent women from having abortions for the Sake of donating feta tissue to people but the regulations make no mention of mice said Mccune whose work has been financed largely by the National institutes of health. The humanized mouse a is potentially quite an important Model for studying aids and other disease said or. Anthony s. Fauci director of the National Institute of allergy and infectious diseases in Bethesda my Mccune said his notion for creating the in Manizer mouse was bom of frustration. In his work with aids patients be developed concepts for therapies that needed to be tested in animate yet the ads virus infects Only human cute. The idea was to insert tissues from human fetal organs into mice with deficient a Monte systems that would not reject the implants. Sach Macy bad been developed at the fax Chase cancer Center in Philadelphia to create mice with human of mime systems Mccune takes the thymus liver and Lymph nodes from human fetuses less than 22 weeks old and divides them into hundreds erf pieces about the size of a Grain of Rice. Using a Microscope he implants a piece of each Organ under the kidneys of Young mice. Within Days the mouse a blood vessels move into the human tissue nourishing it and encouraging it to grow. In a month or two the human or gwm Are the size of blueberries and Are Able to engender the cells of the immune system. Though Small the organs Are functionally Complete Mccune said human immune to cells circulate in the mouse a bloodstream while a Ceils and other human immune system components reside in the liver and thymus. At a glance Monaco she 0 Square Miles. Population 29,000 1989 estimate v Mala language French som by French franc or Mone Gascoe fran overview this resort Center on the Mediterranean s the most Fanous Prince Jaty in. C Europe. Amp has been ruled by a the House of Grimaldi since 1297, except during the French revolution Prince Ranier in is current head of state. Monaco warm climate1 scenery and Monte Carlo Casino and shopping Utrup make h a tourist Mecca. Andorra sfa�.186tt ii reginae tier tallow of Romp 1989 estimate Maja input yer catalan official Spanish and Erenita Curacy French franc Spanish peseta. Overview. The principality of Andorra sits in Fob rugged pyrenees mountains and be jointly administered by France and the roman Catholic Bishop of urge in Spain under an agreement dating to 1278. Tourism Partsc Fauty siting for the chief source of income the capital is Andorra la Vella a Bushong Trade Center. Liechtenstein san Marino is 82 Square Miles 3cg000 1989 pm Imp Bogk act Max Cut my saris franc Oil inv.  in it tie Rhine River Valley unrounded by foe a is. Tourism wipe Cindy around the capital of Vaduz and a name a Fitch Irma Are principal sources of ionae. Low tanks make it a. Of registration for businesses. Stems postal and Corm a Mica tax a Sterna a Houger the a a a issues in own Stamps. Size 24 Square Miles population 23,00 3 1989 estimate Mala language italian currency italian Bra overview the most Serene Republic of san Marino dates bade to the fourth Century and claims to be the oldest Independent state in Europe. The country is dominated by mount Titano on which sits foe capital also named san Marino and several old. Castles. Tourism and the republics distinctive postage Stamps Are foe main sources of Revenue. To plus sunday i. By. November 18,1990ana questions q How can it be rattling hard on one Side of the Street and be dry even sunny on the other a a the phenomenon is most Likely to occur in Northern latitudes in a pattern of summery weather said Fred Gadomsky a meteorologist at Pennsylvania state University in University Park a. It can result from what meteorologists Call a local forcing a where very Small local weather patterns prevail Over broader weather conditions he said. In wintertime Gadomsky explained Broad sweeps of warm air Rise up Over cold air and the lifting mechanism creates Clouds that Rise until they Are Cool enough to precipitate the water vapor they Are saturated with. In summer however warm humid air masses can create such Clouds on a very local basis Gadomsky said a the uneven heating Between a Blacktop parking lot and a nearby Field can be enough to Start air going up Over the More strongly heated part of the landscape a he said and foe Small area of upward moving air is enough to Lead to Clouds and rain